Clinic for Pediatric
Immunology and
Rheumatology

We investigate the genetic and molecular basis of rare immune disorders and translate these discoveries into improved diagnostics and targeted therapies for children with inborn errors of immunity.

PRINCIPAL INVESTIGATOR

Prof. Dr. Kaan Boztug

Director, Clinic for Pediatric Immunology and Rheumatology, University Hospital Bonn

Our work integrates next-generation sequencing, molecular immunology, and systems medicine to investigate genetic causes of rare disorders of hematopoiesis and immune regulation.

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OUR RESEARCH

Research Highlights

Inborn Errors of Immunity

Uniting fields for a greater purpose

The Boztug Laboratory is part of the Clinic for Pediatric Immunology and Rheumatology at the University Hospital Bonn (UKB) and is integrated within the ImmunoSensation Cluster3 of Excellence at the University of Bonn.

Our research combines clinical immunology, genomics, molecular biology, and computational analysis to uncover disease mechanisms in rare immune and hematopoietic disorders.

Genetic & Molecular Discovery

Understanding rare disease mechanisms

By studying patients with naturally occurring genetic variants, we investigate the molecular mechanisms underlying rare immune and hematopoietic disorders.

Genomic analysis is integrated with molecular biology and computational approaches to connect genetic variation with altered immune function.

Genetic and Molecular Discovery research

Precision Medicine

From discovery toward patient benefit

Understanding the genetic and molecular basis of disease provides fundamental insights into human immune function.

Our goal is to translate these discoveries into improved diagnostics and precision-medicine approaches that directly benefit affected children and their families.

MAIN PROJECTS

Monogenic Actinopathies

Investigation of genetic defects affecting the actin cytoskeleton and their consequences for immune-cell development and function.

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Monogenic Hemophagocytic Lymphohistiocytosis

Research into inherited immune dysregulation and the molecular mechanisms underlying familial and monogenic forms of HLH.

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Monogenic Inflammatory Bowel Disease

Identification and functional characterization of genetic causes of very-early-onset and monogenic inflammatory bowel disease.

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Upcoming Events

Annual Lab retreat26 Aug 2026

BBQ party UKB1 Sep 2026

German Society for Immunology (DGfI)15 Sep 2026

22nd Biennial Meeting of ESID14 Oct 2026

Latest Findings and
Publications

Stay informed with our latest research breakthroughs and publications highlighting discoveries across immunology, genetics, and rare diseases.

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Connect with us to make a
difference in science!

GET IN TOUCH TODAY

University Hospital Bonn
Biomedical Center (BMZ 1)
Building 13
Venusberg-Campus 1
53127 Bonn, Germany

JOIN OUR TEAM

Interested in joining the Boztug Laboratory?

We welcome motivated postdoctoral researchers, PhD candidates, and Master's students interested in immunology, human genetics, rare diseases, and translational medicine.